Below is a 15-module study guide: “Artificial Intelligence in Neurosurgery”.
Each module includes (A) 3 recent working YouTube videos (URLs) and (B) 3 basic written guides (good starting reading).

Module 1 — Big Picture: What AI is doing to Neurosurgery now

Videos (YouTube)

https://www.youtube.com/watch?v=tva7eQW2rAE




Written guides

• Narrative overview of AI across neurosurgery (diagnosis, planning, intraop, postop). PMC

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• Broad applications in neurosurgery (diagnostic, predictive, intraop, education). ScienceDirect

Module 2 — AI literacy for neurosurgeons: core concepts + what “good” looks like

Videos (YouTube)

Written guides

• WHO guidance on ethics/governance (principles + risk framing). World Health Organization+1

• FDA overview page for AI in Software as a Medical Device (SaMD). U.S. Food and Drug Administration

• Reporting guidance for AI clinical trials (CONSORT-AI) and protocols (SPIRIT-AI background). equator-network.org+1

Module 3 — Data in neurosurgery: datasets, labeling, bias, leakage, and evaluation

Videos (YouTube)

Written guides

• WHO ethics/governance (bias, accountability, safety framing). World Health Organization

• CONSORT-AI extension (what you must disclose/evaluate in AI intervention trials). equator-network.org

• FDA PCCP guidance (how AI devices can change safely over time). U.S. Food and Drug Administration

Module 4 — Medical imaging deep learning: segmentation fundamentals (the workhorse of neuro-AI)

Videos (YouTube)

Written guides

• Step-by-step 3D U-Net training for BraTS brain tumor segmentation (excellent hands-on guide). LearnOpenCV

• Example research on brain tumor segmentation improvements (good for “what papers look like”). PMC

• Neurosurgery AI narrative review (helps connect segmentation → surgical decisions). PMC

Module 5 — Brain tumors: radiomics + deep learning for diagnosis, grading, prognosis

Videos (YouTube)

Written guides

• Neurosurgery AI narrative review (brain tumor imaging + planning themes). PMC

• AI in diagnostic neurosurgery trend analysis (useful survey-style perspective). AME Surgical Journal

• Example 2025 brain tumor segmentation paper (read the abstract, methods, limitations). PMC

Module 6 — Stroke & neurovascular triage: AI for time-to-treatment workflows

Videos (YouTube)

Written guides

• Viz.ai webinars hub (browse neuro/vascular workflow content). Viz.ai

• Example discussion of AI-powered stroke coordination (workflow impact framing). Viz.ai

• FDA AI SaMD overview (relevant because stroke triage tools are typically SaMD). U.S. Food and Drug Administration

Module 7 — Spine: navigation, AR, and AI-assisted guidance

Videos (YouTube)

Written guides

• Neurosurgery AI narrative review (intraop guidance/navigation themes). PMC

• WHO guidance (risk, governance, equity—important for device-assisted surgery). World Health Organization

• FDA PCCP guidance (important if navigation/AR tools include adaptive AI features). U.S. Food and Drug Administration

Module 8 — Surgical robotics + autonomy: where AI meets instruments

Videos (YouTube)

Written guides

• 2025 systematic review/meta-analysis on AI-driven robotic surgery (broad surgery, still highly relevant). PMC

• JHU report on robots trained by watching surgery videos (good “state of the art” story). The Hub

• FDA AI SaMD overview (regulation mindset for AI features in robotic platforms). U.S. Food and Drug Administration

Module 9 — Smart OR: navigation robots, device integration, and “networked OR”

Videos (YouTube)

Written guides

• FDA PCCP guidance (continuous improvement without constant re-submissions—key concept). U.S. Food and Drug Administration

• PCCP “guiding principles” page (context + GMLP mention). U.S. Food and Drug Administration

• Neurosurgery AI narrative review (how these technologies fit clinically). PMC

Module 10 — Intraoperative imaging & therapy: iMRI, ioUS, focused ultrasound, BBB opening

Videos (YouTube)

Written guides

• Focused Ultrasound Foundation: brain tumors and BBB-opening context. Focused Ultrasound Foundation

• Dec 2025 report of survival benefit signal using focused ultrasound BBB opening (helpful for “clinical maturity” context). University of Maryland

• Multicenter study: AI improving intraoperative ultrasound for glioma (ioUS + AI). PMC

Module 11 — Functional neurosurgery: DBS, adaptive/closed-loop systems, and AI signal processing

Videos (YouTube)

Written guides

• Medtronic announcement on adaptive DBS (good high-level description of closed-loop DBS). Medtronic News

• Neurosurgery AI narrative review (functional applications overview). PMC

• WHO ethics/governance (especially relevant for implantable AI/closed-loop systems). World Health Organization

Module 12 — Epilepsy surgery: lesion detection, outcome prediction, seizure forecasting

Videos (YouTube)

Written guides

• Cleveland Clinic podcast page: AI-inspired future directions in epilepsy surgery (intro reading). Cleveland Clinic

• Example 2024 paper using stereo-EEG methods to identify targets (good for “data → surgical target” thinking). PMC

• Neurosurgical education AI paper (education + decision-support implications). SpringerLink

Module 13 — Brain-computer interfaces and neuroprosthetics: decoding, privacy, and translation

Videos (YouTube)

Written guides

• WHO ethics/governance (privacy, consent, human oversight are central in BCI). World Health Organization

• Neurosurgery AI narrative review (BCI and broader AI scope context). PMC

• Microsoft Research talk page on decoding the human brain in awake surgery (background reading). Microsoft

Module 14 — LLMs in neurosurgery practice: documentation, literature review, patient communication, decision support

Videos (YouTube)

Important note: the second link above is a playlist episode listing from NEJM AI Grand Rounds results—use this direct video instead (same topic category), which is clearly valid:

Written guides

• FDA AI SaMD overview (LLM-based tools can fall into SaMD depending on function/claims). U.S. Food and Drug Administration

• WHO ethics/governance (hallucinations + accountability + transparency concepts). World Health Organization

• CONSORT-AI / SPIRIT-AI context for evaluating AI interventions responsibly. equator-network.org+1

Module 15 — Translation to real clinical deployment: regulation, monitoring, updates, and safety

Videos (YouTube)

Written guides

• FDA PCCP final guidance page for AI-enabled devices (core regulatory concept). U.S. Food and Drug Administration

• FDA PCCP “guiding principles” page (includes Good ML Practice context). U.S. Food and Drug Administration

• CONSORT-AI (how to report/evaluate AI interventions in clinical trials). equator-network.org